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rplL [2019-06-07 17:11:54]
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rplL [2019-06-07 17:11:54]

ribosomal protein L12
locus
BSU01050
pI
4.36
mw
12.61 kDa
protein length
123 aa Sequence Blast
gene length
372 bp Sequence Blast
function
translation
product
ribosomal protein L12 (BL9)
essential
yes
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.4|Ribosomal proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    120,607 → 120,978

    Phenotypes of a mutant

  • essential [Pubmed|23002217,12682299]

    • The protein

    Protein family

  • [SW|ribosomal protein] L12P family (according to Swiss-Prot)

    • Structure

  • [PDB|3J9W] (the [SW|ribosome]) [Pubmed|25903689]

    • [SW|Localization]

  • membrane associated [Pubmed|18763711]

    • additional information

  • belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

    • Expression and Regulation

    Operons

    genes
    [gene|5EF3A7953AA97D2B44C967542A53FEA7F36D7BA3|rplJ]-[gene|E72910604D3DC2A62AE8A951F55570EA2838B250|rplL]
    description
    [Pubmed|26101249]

    regulatory mechanism

  • [protein|5EF3A7953AA97D2B44C967542A53FEA7F36D7BA3|RplJ]: termination, at excess of the [protein|5EF3A7953AA97D2B44C967542A53FEA7F36D7BA3|RplJ]-[protein|E72910604D3DC2A62AE8A951F55570EA2838B250|RplL]4 complex, in [regulon|5EF3A7953AA97D2B44C967542A53FEA7F36D7BA3|RplJ regulon]
  • [regulon|stringent response|stringent response]: negative regulation, in [regulon|stringent response|stringent response]
  • [protein|E72910604D3DC2A62AE8A951F55570EA2838B250|RplL]: termination, at excess of the [protein|5EF3A7953AA97D2B44C967542A53FEA7F36D7BA3|RplJ]-[protein|E72910604D3DC2A62AE8A951F55570EA2838B250|RplL]4 complex, in [regulon|E72910604D3DC2A62AE8A951F55570EA2838B250|RplL regulon]

    • regulation

  • termination/ antitermination ([protein|5EF3A7953AA97D2B44C967542A53FEA7F36D7BA3|L10]-[protein|E72910604D3DC2A62AE8A951F55570EA2838B250|L12]4 complex) [Pubmed|26101249]
    • view in new tab

    genes
    [gene|F94A1C14912F35ADB4C611AA17D55268CC26160D|rplK]-[gene|44D4CE353E1E532664A508CBE8B49AC8BB861B53|rplA]-[gene|E4D89640D0F0A31A2814D20FB5425FDB0B46A43D|BSU_misc_RNA_3]-[gene|5EF3A7953AA97D2B44C967542A53FEA7F36D7BA3|rplJ]-[gene|E72910604D3DC2A62AE8A951F55570EA2838B250|rplL]
    description
    [pubmed|22383849]

    regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, [pubmed|11948165], in [regulon|stringent response|stringent response]

    • regulation

  • [protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
    • view in new tab

    References

  • 7657605,17981968,23912278,18763711,19653700,23002217,15378759,18247578,26101249,25903689,28516784